Cool-Burn: Five-Gene Menthol Pathway Engineering with IFI-C ~85,000 via TRPM8/TRPV1 Co-Modulation

Engineering a biphasic cool-burn sensory experience through heterologous expression of the complete five-gene menthol biosynthesis pathway alongside capsaicinoid components, enabling simultaneous activation of TRPM8 (cool/menthol receptor) and TRPV1 (heat receptor). Targets an IFI-C score of approximately 85,000 — a dual-polarity sensory position not achievable through formulation alone. Construct specifications cover TRPM8 agonist and TRPV1 co-activation for consumer and commercial applications. PDF and full specifications in preparation.