The Scoville Splice Capsaicin Design Platform: An Integrated Computational and Synthetic Biology Framework for Full-Spectrum Flavor Engineering

Platform paper describing the complete Scoville Splice computational and synthetic biology pipeline — from receptor-targeted flavor design through RNA-seq, metabolic flux modeling, protein language model mutagenesis, CRISPR construct design, and the Iyengar Flavor Index scoring framework. Synthesizes findings across all ten receptor-axis papers into a unified engineering methodology for full-spectrum flavor phenotype design. Manuscript in preparation.