Genomic data displayed on a large laboratory screen

Platform

Looking for a CropOS alternative?

Benson Hill's CropOS is no longer available. The Iyengar Flavor Index platform covers receptor-level flavor design for teams that need to keep working.

1,000

constructs in catalog

8

receptor axes (IFI)

40

specialty catalogs

Free

catalog search

01

What happened to CropOS

Benson Hill filed for Chapter 7 bankruptcy in early 2025, ceased operations, and shut down CropOS. The platform, which let plant breeders design flavor traits using a proprietary genomic dataset, is no longer accessible. Teams that relied on it for flavor trait specification, construct discovery, and crop design workflows need an alternative.

The underlying problem CropOS was solving โ€” that flavor design lacked a quantitative computational layer โ€” has not gone away. The question is what tools exist now.

02

How the IFI platform covers the same space

Receptor model

8-axis IFI instead of genomic markers

CropOS mapped crop genetics to flavor outcomes via a proprietary trait model. The IFI maps constructs directly to receptor responses โ€” TRPV1, TRPM5, T1R heterodimers, CaSR, and others. The receptor layer is agnostic to organism; the same axis scores apply whether you are working in pepper, tomato, coffee, hops, or a novel crop.

Catalog

1,000 constructs, 40 specialty catalogs

CropOS required you to work within Benson Hill's breeding pipeline. The IFI platform lets you search, filter, and license constructs directly from a catalog of 1,000 entries organized by receptor axis, organism, and application. No plant breeding commitment required to explore the design space.

Organism coverage

13 organisms beyond pepper

Tomato, coffee, vanilla, hops, garlic, ginger, tea, blueberry, sugarcane, mint, cocoa, and grape each have dedicated organism catalogs. If your CropOS work spanned multiple crops, the IFI covers the full range without a separate pipeline per species.

Precision

Quantitative axis scores, not trait predictions

CropOS outputs were trait probabilities tied to Benson Hill's proprietary training data. IFI scores are grounded in published receptor biology โ€” each axis has a defined receptor basis, a measurement protocol, and a confidence interval. The score is interpretable independently of the platform that generated it.

API access

Programmatic query at enterprise tier

CropOS offered API access for integration into larger design pipelines. The IFI platform does the same โ€” platform tier includes API access for querying IFI scores, pulling construct records, and exporting data into existing lab workflows. The API schema is documented and stable.

No lock-in

Constructs license independently

CropOS constructs were inseparable from Benson Hill's breeding program โ€” you could not take the construct and work with another partner. IFI constructs license independently under standard commercial terms. You can take a licensed construct to any CRISPR-capable lab.

03

A direct comparison

Flavor model
Genomic trait markers (proprietary) โ†’ IFI receptor axes (published basis)
Organism coverage
Soy, corn, pea (Benson Hill crops) โ†’ 13+ organisms, organism-agnostic model
Catalog size
Benson Hill pipeline only โ†’ 1,000 constructs, 40 specialty catalogs
Access model
SaaS with Benson Hill pipeline dependency โ†’ SaaS + API, independent licensing
Availability
Shut down Q1 2025 โ†’ Active, production platform
Entry point
Paid tier required โ†’ Free catalog search, paid platform tier

The comparison is not meant to diminish CropOS, which was an early attempt at quantifying crop flavor design. The difference is that the IFI model starts from receptor biology rather than a proprietary training set, which means the scores transfer across organisms and are auditable against published science.

04

Getting started

The catalog search is free and does not require an account. It is the fastest way to see whether the constructs you need are available and what their IFI profiles look like. If your work was in a specific organism or flavor axis, the organism and axis catalogs are the fastest entry points.

Teams migrating an active flavor design program from CropOS can request a transition consultation โ€” a structured session that maps your previous CropOS workflows to IFI equivalents, identifies construct candidates, and establishes a licensing path. Use the custom quote form to describe the scope.

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