IFI-K · CaSR Enhance

Specimen SS-F-KOK-114 // KOKUMI · IFI-K

CaSR Enhance V-AG-B

Capsicum annuum

Pepper

Tier VCaSR Enhance

Target Trait

5.17×

fold-change

CaSR receptor activation fold-change over wild-type

Technical Specifications

Genomic Edits

10

GC Content

53.6%

Construct Length

3,140 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

775.5

Pathway Edits

  • Near-maximal CaSR constitutive activation
  • All negative modulators removed
  • Ultrasensitive switch behavior engineering
  • Full second-messenger cascade amplification
  • Transcriptional positive-feedback network
  • Epigenetic mark writing for stable expression
  • Chaperone optimization for receptor surface density
  • Ubiquitin-proteasome degradation resistance edit
  • Signal integration hub consolidation

Key Interventions

maximal receptor activation with full cascade unlockstable expression via epigenetic programming

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
775.5
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Elite culinary bioactive for Michelin-tier applications

License

$549 · Tier V License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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