IFI-K · CaSR Enhance

Specimen SS-F-KOK-111 // KOKUMI · IFI-K

CaSR Enhance IV-IV-A

Capsicum annuum

Pepper

Tier IVCaSR Enhance

Target Trait

3.88×

fold-change

CaSR receptor activation fold-change over wild-type

Technical Specifications

Genomic Edits

8

GC Content

52.1%

Construct Length

2,820 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

582

Pathway Edits

  • CaSR agonist-independent constitutive activity induction
  • Transmembrane domain helix contact remodel
  • Gi/o pathway complete uncoupling
  • Sustained PLCβ activation circuit
  • Calcineurin-NFAT positive-feedback loop
  • COX-2 anti-inflammatory suppression
  • Transcription factor AP-1 activation lock
  • MAP3K signal amplifier insertion

Key Interventions

constitutive low-level activation inductionPLCβ sustained engagement

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
582
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Restaurant-grade kokumi stock concentrate

License

$249 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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