IFI-K · CaSR Enhance

Specimen SS-F-KOK-096 // KOKUMI · IFI-K

CaSR Enhance II-IV-B

Capsicum annuum

Pepper

Tier IICaSR Enhance

Target Trait

3.02×

fold-change

CaSR receptor activation fold-change over wild-type

Technical Specifications

Genomic Edits

7

GC Content

49.1%

Construct Length

2,180 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

453

Pathway Edits

  • CaSR biased agonism remodel toward Gαq
  • GPCR kinase GRK2/3 expression reduction
  • β-arrestin2 recruitment impairment
  • Gαq11-PLCβ interface lock edit
  • Diacylglycerol kinase silencing
  • Protein kinase C translocation enhancer

Key Interventions

biased Gαq signaling lockGRK-mediated desensitization removal

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
453
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Spice blend kokumi amplifier ingredient

License

$149 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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