CaSR Enhance II-AG-A

Capsicum annuum

Pepper

Tier IICaSR Enhance

Target Trait

2.63×

fold-change

CaSR receptor activation fold-change over wild-type

Technical Specifications

Genomic Edits

GC Content

49.1%

Construct Length

2,180 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

394.5

Pathway Edits

CaSR biased agonism remodel toward Gαq
GPCR kinase GRK2/3 expression reduction
β-arrestin2 recruitment impairment
Gαq11-PLCβ interface lock edit
Diacylglycerol kinase silencing
Protein kinase C translocation enhancer

Key Interventions

biased Gαq signaling lockGRK-mediated desensitization removal

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

—

IFI-B

—

IFI-K

394.5

IFI-C

—

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Spice blend kokumi amplifier ingredient

License

$99 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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