IFI-K · CaSR Enhance

Specimen SS-F-KOK-088 // KOKUMI · IFI-K

CaSR Enhance I-IV-B

Capsicum annuum

Pepper

Tier ICaSR Enhance

Target Trait

2.3×

fold-change

CaSR receptor activation fold-change over wild-type

Technical Specifications

Genomic Edits

6

GC Content

47.6%

Construct Length

1,860 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

345

Pathway Edits

  • CaSR extracellular binding site Trp718→Tyr
  • Capsaicin-independent ligand scaffold edit
  • GRM7 cross-antagonism silencing
  • Gs/Gq coupling switch
  • PP2A phosphatase suppression

Key Interventions

CaSR binding site affinity increaseGs-to-Gq pathway redirection

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
345
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Pepper-derived kokumi base for hot sauce applications

License

$99 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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