Calcium Flux IV-BL-A

Allium cepa

Onion

Tier IVCalcium Flux

Target Trait

2.78×

fold-change

CaSR-mediated intracellular Ca2+ flux fold-change

Technical Specifications

Genomic Edits

GC Content

49.3%

Construct Length

2,490 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

417

Pathway Edits

CaSR homodimer interface strengthening
Allosteric modulator binding site engineering
Gβγ coupling optimization
TRPV4 co-expression cassette
IP3R2/3 sensitization dual edit
STIM1-Orai1 SOCE potentiation
PKA inhibitory cascade removal

Key Interventions

multi-channel Ca2+ influx coordinationSOCE pathway co-activation

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

—

IFI-B

—

IFI-K

417

IFI-C

—

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Fine dining application with nuanced Ca2+ response

License

$249 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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