IFI-C · Arctic Burn

Specimen SS-F-CLB-192 // COOL BURN · IFI-C

Arctic Burn IV-IV-B

Capsicum chinense

Pepper

Tier IVArctic Burn

Target Trait

2.76 ratio

TRPM8/TRPV1 ratio

TRPM8/TRPV1 activation ratio

Technical Specifications

Genomic Edits

14

GC Content

45.6%

Construct Length

4,280 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

TRPM8 + TRPV1

IFI Score

1,104

Pathway Edits

  • TRPM8 gain-of-function variant M682T insertion
  • TRPV1 ultra-sensitization loop (IP3R-PKA signaling axis)
  • Icilin-analog biosynthesis cluster ICIA1-3 full integration
  • Capsiate pathway maximization cassette (pAMT, KAS, BCAT)
  • Dual-channel co-localization scaffold protein DCL1 insertion
  • Arctic terpene synthase ATS full gene cluster integration
  • Cooling-intensity regulator CFR1 gain-of-function allele
  • Secondary messenger cAMP amplification edit (PDE4 knockout)

Key Interventions

Maximum-intensity dual-channel co-activationIcilin-analog compound overproduction and accumulationExtreme TRPM8 gain-of-function channel activationTRPV1 hyper-sensitization for intense burn inductionArctic cool compound + capsiate burn co-expression systemDual-sensation intensity ceiling expansion beyond natural rangeCold-receptor saturation-level agonist engineeringMulti-compound cool-burn synergy cascade optimization

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
1,104
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Extreme dual-sensation product development, competitive heat-and-cool market innovation, high-impact functional beverage formats, and novel cool-burn nutraceutical platforms.

License

$299 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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