IFI-C · Menthol Analog

Specimen SS-F-CLB-104 // COOL BURN · IFI-C

Menthol Analog III-IV-B

Capsicum chinense

Pepper

Tier IIIMenthol Analog

Target Trait

1.55 ratio

TRPM8/TRPV1 ratio

TRPM8/TRPV1 activation ratio

Technical Specifications

Genomic Edits

9

GC Content

44.4%

Construct Length

3,280 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

TRPM8 + TRPV1

IFI Score

620

Pathway Edits

  • Pulegone reductase (PR) full-pathway overexpression
  • Menthofuran synthase (MFS) loss-of-function knockout
  • TRPM8 allosteric enhancer peptide MAP1 insertion
  • Isopulegol oxidase branch pathway enhancement cassette
  • Cold-sensing transcription factor TF-C1 upregulation

Key Interventions

Non-menthol TRPM8 agonist compound biosynthesisEnhanced menthol-analog metabolite accumulationTRPM8 EC50 reduction via allosteric modulationReduced menthofuran off-note compound generationProlonged cool-burn activation kinetic extension

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
620
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Non-menthol cooling ingredient development, bitter-masking applications, oral care and pharmaceutical excipient engineering, and novel cooling-sensation platforms free of classical menthol.

License

$199 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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