IFI-C · Dual Sensation

Specimen SS-F-CLB-031 // COOL BURN · IFI-C

Dual Sensation IV-IV-A

Capsicum chinense

Pepper

Tier IVDual Sensation

Target Trait

0.6 ratio

TRPM8/TRPV1 ratio

TRPM8/TRPV1 activation ratio

Technical Specifications

Genomic Edits

7

GC Content

45.6%

Construct Length

3,240 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Receptor Target

TRPM8 + TRPV1

IFI Score

240

Pathway Edits

  • TRPM8 promoter::CaMV 35S upregulation cassette
  • Menthol synthase (MnS1) codon-optimized overexpression
  • TRPV1 channel expression maintenance construct

Key Interventions

Balanced TRPM8/TRPV1 dual-channel co-activationL-menthol steady-state tissue concentration elevationSimultaneous cool-hot afferent neural signal co-induction

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
240
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Mint-forward beverages, cooling confectionery, oral care formulations, and dual-sensation chewing gum requiring balanced cool-burn activation at approachable intensity levels.

License

$249 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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