ATCC-4124 Y5-ARO+-PH

Saccharomyces cerevisiae

Yeast

ATCC-4124 SeriesTier 5

Target Trait

300

mg/L

Reported target: 300 mg/L capsaicin

Technical Specifications

Genomic Edits

GC Content

(41%)

Construct Length

27,700 bp

Promoter System

TEF1/PGK1/GAL1/ADH1 constitutive array

Expression System

Yeast genomic integration (4 loci)

Host Strain

ATCC-4124

Pathway Edits

ARO4(K229L) feedback-resistant (2× copy number)
ARO7(G141S) feedback-resistant (2× copy number)
ΔARO10
ΔPAD1
Additional ARO4 copy at HO locus
TKL1/TKL2 overexpression for E4P supply

Key Interventions

Doubled ARO4 dosage amplifies shikimate pathway fluxPentose phosphate pathway enhancement for E4P

Application Domains

PharmaceuticalResearch

Intended Use

Robust extreme-condition chassis producing 300 mg/L capsaicin under stress fermentation; appropriate for pharmaceutical-grade capsaicin APIs and research applications..

Access

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