PE-2 Y5-MAX-PH

Saccharomyces cerevisiae

Yeast

PE-2 SeriesTier 5

Target Trait

300

mg/L

Reported target: 300 mg/L capsaicin

Technical Specifications

Genomic Edits

GC Content

(41%)

Construct Length

28,900 bp

Promoter System

TEF1/PGK1/GAL1/ADH1 constitutive array

Expression System

Yeast genomic integration (4 loci)

Host Strain

PE-2

Pathway Edits

ARO4(K229L) feedback-resistant (2× copy)
ARO7(G141S) feedback-resistant (2× copy)
ΔARO10, ΔPAD1, ΔPOX1 triple knockout
PAL1 overexpression + Pun1(S39L+L345G)
Full 9-gene cassette + TKL1/TKL2
ESM2 dual chaperone variant

Key Interventions

All knockouts combined with all overexpressionsMaximum-yield configuration for industrial productionDual chaperone + dual Pun1 mutant stack

Application Domains

PharmaceuticalResearch

Intended Use

High-yield Brazilian industrial strain achieving up to 300 mg/L capsaicin; optimized for pharmaceutical-grade capsaicin APIs and research applications. with maximum combined edits stack.

Access

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