CEN.PK-B Y4-ARO+-FD

Saccharomyces cerevisiae

Yeast

CEN.PK-B SeriesTier 4

Target Trait

200

mg/L

Reported target: 200 mg/L capsaicin

Technical Specifications

Genomic Edits

GC Content

(41%)

Construct Length

27,200 bp

Promoter System

TEF1/PGK1/GAL1/ADH1 constitutive array

Expression System

Yeast genomic integration (4 loci)

Host Strain

CEN.PK-B

Pathway Edits

ARO4(K229L) feedback-resistant (2× copy number)
ARO7(G141S) feedback-resistant (2× copy number)
ΔARO10
ΔPAD1
Additional ARO4 copy at HO locus
TKL1/TKL2 overexpression for E4P supply

Key Interventions

Doubled ARO4 dosage amplifies shikimate pathway fluxPentose phosphate pathway enhancement for E4P

Application Domains

Food ManufacturingIndustrial

Intended Use

Pharma-grade CEN.PK derivative delivering 200 mg/L capsaicin with low endotoxin profile; designed for food-grade fermentation and industrial capsaicin production..

Access

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