Arctic Burn T5-BL-PH

Capsicum annuum

Hungarian Wax

Arctic Burn SeriesTier 5

Target Trait

2.5

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2.5

Technical Specifications

Genomic Edits

GC Content

(57%)

Construct Length

11,260 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

Arctic burn peak TRPM8 engineering with voltage-sensor domain stabilizationMaximum TRPM8/TRPV1 biphasic axis via full thermosensory rewiring

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Arctic Burn T5 at TRPM8/TRPV1 ratio 2.5. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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