Commercial Access Only

Specimen SS-COM-CLB-0979 // COOL-BURN

Arctic Burn T4-IV-RS

Capsicum annuum

Hungarian Wax

Arctic Burn SeriesTier 4

Target Trait

2.33

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2.33

Technical Specifications

Genomic Edits

12

GC Content

(55%)

Construct Length

10,240 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

  • TRPM8 gain-of-function
  • TRPV1 co-expression tuning
  • Icilin analog synthesis

Key Interventions

Arctic burn peak TRPM8 engineering with voltage-sensor domain stabilizationMaximum TRPM8/TRPV1 biphasic axis via full thermosensory rewiring

Application Domains

Research

Intended Use

Research-grade Arctic Burn T4 construct; TRPM8/TRPV1 ratio 2.33. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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