Menthol Bridge T5-BL-PH

Capsicum chinense

Bhut Jolokia

Menthol Bridge SeriesTier 5

Target Trait

2.3

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2.3

Technical Specifications

Genomic Edits

GC Content

(55%)

Construct Length

11,040 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

Menthol and icilin co-production pathway via dual-module terpene synthaseTRPM8/TRPV1 ratio optimization scaffold with feedback-insensitive promoters

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Menthol Bridge T5 at TRPM8/TRPV1 ratio 2.3. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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