Menthol Bridge T4-IV-PH

Capsicum chinense

Bhut Jolokia

Menthol Bridge SeriesTier 4

Target Trait

2.13

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2.13

Technical Specifications

Genomic Edits

GC Content

(54%)

Construct Length

10,020 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

TRPM8 gain-of-function
TRPV1 co-expression tuning
Icilin analog synthesis

Key Interventions

Menthol and icilin co-production pathway via dual-module terpene synthaseTRPM8/TRPV1 ratio optimization scaffold with feedback-insensitive promoters

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Menthol Bridge T4 at TRPM8/TRPV1 ratio 2.13. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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