Commercial Access Only

Specimen SS-COM-CLB-0777 // COOL-BURN

Biphasic Grade T4-IV-PH

Capsicum annuum

Thai Bird

Biphasic Grade SeriesTier 4

Target Trait

1.93

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.93

Technical Specifications

Genomic Edits

10

GC Content

(52%)

Construct Length

9,800 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

  • TRPM8 gain-of-function
  • TRPV1 co-expression tuning
  • Icilin analog synthesis

Key Interventions

Full biphasic thermosensory axis with tissue-specific temporal gatingTRPM8 + TRPV1 stoichiometric tuning via protein scaffold co-localization

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Biphasic Grade T4 at TRPM8/TRPV1 ratio 1.93. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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