Commercial Access Only

Specimen SS-COM-CLB-0689 // COOL-BURN

Cooling Edge T5-BL-RS

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 5

Target Trait

2

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2

Technical Specifications

Genomic Edits

10

GC Content

(52%)

Construct Length

10,600 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Pathway Edits

  • TRPM8 Y745H gain-of-function
  • TRPV1 co-regulation
  • Full biphasic thermosensory axis
  • Menthol + Icilin co-production

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

Research

Intended Use

Research-grade Cooling Edge T5 construct; TRPM8/TRPV1 ratio 2. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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