Cooling Edge T5-AG-GX

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 5

Target Trait

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 2

Technical Specifications

Genomic Edits

GC Content

(52%)

Construct Length

10,600 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

Food ManufacturingPharmaceuticalAgricultural BiotechIndustrialResearch

Intended Use

Multi-domain Cooling Edge T5 commercial construct; TRPM8/TRPV1 ratio 2. Full regulatory documentation package spanning food manufacturing, pharmaceutical, agricultural biotech, industrial, and research applications. Broadest deployment envelope in the Cool-Burn portfolio.

Access

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