Cooling Edge T4-PR-RS

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 4

Target Trait

1.8

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.8

Technical Specifications

Genomic Edits

GC Content

(51%)

Construct Length

9,580 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-mediated

Pathway Edits

TRPM8 gain-of-function
TRPV1 co-expression tuning
Icilin analog synthesis

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

Research

Intended Use

Research-grade Cooling Edge T4 construct; TRPM8/TRPV1 ratio 1.8. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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