Cooling Edge T4-BL-PH

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 4

Target Trait

1.8

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.8

Technical Specifications

Genomic Edits

GC Content

(51%)

Construct Length

9,580 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Pathway Edits

TRPM8 gain-of-function
TRPV1 co-expression tuning
Icilin analog synthesis

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Cooling Edge T4 at TRPM8/TRPV1 ratio 1.8. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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