Cooling Edge T1-PR-PH

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 1

Target Trait

1.2

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.2

Technical Specifications

Genomic Edits

GC Content

(46%)

Construct Length

6,520 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-mediated

Pathway Edits

TRPM8 partial activation scaffold
TRPV1 baseline maintenance

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Cooling Edge T1 at TRPM8/TRPV1 ratio 1.2. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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