Cooling Edge T1-AG-RS

Capsicum chinense

Carolina Reaper

Cooling Edge SeriesTier 1

Target Trait

1.2

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.2

Technical Specifications

Genomic Edits

GC Content

(46%)

Construct Length

6,520 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Pathway Edits

TRPM8 partial activation scaffold
TRPV1 baseline maintenance

Key Interventions

TRPM8 Y745H gain-of-function variant with enhanced cold threshold shiftIcilin analog biosynthesis pathway via heterologous terpene enzymes

Application Domains

Research

Intended Use

Research-grade Cooling Edge T1 construct; TRPM8/TRPV1 ratio 1.2. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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