Commercial Access Only

Specimen SS-COM-CLB-0598 // COOL-BURN

Ice-Fire Scale T5-IV-IN

Capsicum annuum

Serrano

Ice-Fire Scale SeriesTier 5

Target Trait

1.8

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.8

Technical Specifications

Genomic Edits

9

GC Content

(51%)

Construct Length

10,380 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

  • TRPM8 Y745H gain-of-function
  • TRPV1 co-regulation
  • Full biphasic thermosensory axis
  • Menthol + Icilin co-production

Key Interventions

TRPM8 constitutive gain-of-function via S1 helix engineeringTRPV1 co-regulated expression with convergent promoter architecture

Application Domains

Industrial

Intended Use

Industrial-grade Ice-Fire Scale construct (T5); TRPM8/TRPV1 ratio 1.8. Engineered for large-scale cooling-sensation ingredient production, non-food thermosensory material manufacturing, industrial biochemical processing, and high-volume dual-receptor compound biosynthesis.

Access

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