Commercial Access Only

Specimen SS-COM-CLB-0479 // COOL-BURN

Thermal Contrast T4-IV-RS

Capsicum chinense

Ghost Pepper

Thermal Contrast SeriesTier 4

Target Trait

1.4

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.4

Technical Specifications

Genomic Edits

8

GC Content

(49%)

Construct Length

9,360 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

  • TRPM8 gain-of-function
  • TRPV1 co-expression tuning
  • Icilin analog synthesis

Key Interventions

Biphasic thermal axis co-engineering (cold 8–28°C + heat 42°C+ gates)TRPM8/TRPV1 simultaneous co-activation scaffold with ratio stabilizer

Application Domains

Research

Intended Use

Research-grade Thermal Contrast T4 construct; TRPM8/TRPV1 ratio 1.4. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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