Commercial Access Only

Specimen SS-COM-CLB-0477 // COOL-BURN

Thermal Contrast T4-IV-PH

Capsicum chinense

Ghost Pepper

Thermal Contrast SeriesTier 4

Target Trait

1.4

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.4

Technical Specifications

Genomic Edits

8

GC Content

(49%)

Construct Length

9,360 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro cell-free

Host Strain

Cell-free

Pathway Edits

  • TRPM8 gain-of-function
  • TRPV1 co-expression tuning
  • Icilin analog synthesis

Key Interventions

Biphasic thermal axis co-engineering (cold 8–28°C + heat 42°C+ gates)TRPM8/TRPV1 simultaneous co-activation scaffold with ratio stabilizer

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Thermal Contrast T4 at TRPM8/TRPV1 ratio 1.4. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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