TRPM8 Tier T5-AG-GX

Capsicum annuum

Jalapeño

TRPM8 Tier SeriesTier 5

Target Trait

1.4

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.4

Technical Specifications

Genomic Edits

GC Content

(49%)

Construct Length

10,160 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

TRPM8 multi-copy overexpression via tandem promoter architectureTRPV1 concurrent expression scaffold with independent terminator

Application Domains

Food ManufacturingPharmaceuticalAgricultural BiotechIndustrialResearch

Intended Use

Multi-domain TRPM8 Tier T5 commercial construct; TRPM8/TRPV1 ratio 1.4. Full regulatory documentation package spanning food manufacturing, pharmaceutical, agricultural biotech, industrial, and research applications. Broadest deployment envelope in the Cool-Burn portfolio.

Access

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