TRPM8 Tier T1-PR-PH

Capsicum annuum

Jalapeño

TRPM8 Tier SeriesTier 1

Target Trait

0.6

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 0.6

Technical Specifications

Genomic Edits

GC Content

(43%)

Construct Length

6,080 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-mediated

Pathway Edits

TRPM8 partial activation scaffold
TRPV1 baseline maintenance

Key Interventions

TRPM8 multi-copy overexpression via tandem promoter architectureTRPV1 concurrent expression scaffold with independent terminator

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; TRPM8 Tier T1 at TRPM8/TRPV1 ratio 0.6. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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