Cool Peak T5-AG-RS

Capsicum annuum

Cayenne

Cool Peak SeriesTier 5

Target Trait

1.1

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.1

Technical Specifications

Genomic Edits

GC Content

(48%)

Construct Length

9,940 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

Ubiquitin::TRPM8-high-expression dual-promoter cassetteTRPV1 channel stabilization via auxiliary subunit co-expression

Application Domains

Research

Intended Use

Research-grade Cool Peak T5 construct; TRPM8/TRPV1 ratio 1.1. Optimized for mechanistic studies of biphasic thermosensation, TRPM8/TRPV1 ion channel co-activation kinetics, dual-receptor pharmacology screening, and cool-burn sensation pathway dissection.

Access

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