Cool Peak T5-AG-PH

Capsicum annuum

Cayenne

Cool Peak SeriesTier 5

Target Trait

1.1

TRPM8/TRPV1 ratio

Reported target: TRPM8/TRPV1 ratio 1.1

Technical Specifications

Genomic Edits

GC Content

(48%)

Construct Length

9,940 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Pathway Edits

TRPM8 Y745H gain-of-function
TRPV1 co-regulation
Full biphasic thermosensory axis
Menthol + Icilin co-production

Key Interventions

Ubiquitin::TRPM8-high-expression dual-promoter cassetteTRPV1 channel stabilization via auxiliary subunit co-expression

Application Domains

PharmaceuticalResearch

Intended Use

Pharmaceutical-grade dual thermosensory construct; Cool Peak T5 at TRPM8/TRPV1 ratio 1.1. Validated for topical analgesic formulation development, TRPM8/TRPV1 modulator pharmacology, thermosensory pain-relief delivery systems, and preclinical cold/heat receptor research.

Access

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