Lactic Acid Umami I-IV-A

Saccharomyces cerevisiae

Yeast

Tier ILactic Acid Umami

Target Trait

1×

fold-change

Lactic acid umami taste potentiation index

Technical Specifications

SKU

SS-F-UMA-687

Genomic Edits

GC Content

44.7-50.7%

Construct Length

2,070 bp

Promoter System

T7/SP6 cell-free

Expression System

Cell-free T7/SP6 in-vitro

Host Strain

Cell-free

Receptor Target

mGluR1 / TAS1R1-TAS1R3

IFI Score

100

Pathway Edits

ScLDHA L-lactate dehydrogenase A heterologous expression from Lactobacillus helveticus for de-novo lactic acid production in yeast fermentation
ScPDC1 pyruvate decarboxylase partial suppression (40%) to redirect pyruvate from ethanol pathway toward lactate via introduced LDHA

Key Interventions

Lactic acid umami potentiation via LDHA introduction and PDC suppression for yeast-derived lactic acid as mGluR1 potentiating organic acidPyruvate-to-lactate flux engineering targeting organic acid-mediated umami persistence in fermented food matricesGlycolytic flux amplification via PGK1 upregulation for sustained lactic acid production throughout yeast fermentation

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

100

IFI-B

—

IFI-K

—

IFI-C

—

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Yeast-based fermentation flavor ingredients where lactic acid contributes umami persistence and mouthfeel. Applicable to sourdough flavor concentrates, fermented condiment bases, and natural flavor extracts.

License

$299 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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