GABA-mGluR1 II-BL-A

Solanum lycopersicum

Tomato

Tier IIGABA-mGluR1

Target Trait

1.78×

fold-change

GABA mGluR1 allosteric modulation index

Technical Specifications

SKU

SS-F-UMA-451

Genomic Edits

GC Content

43.5-49.5%

Construct Length

2,849 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic particle bombardment

Host Strain

Particle Gun

Receptor Target

mGluR1 / TAS1R1-TAS1R3

IFI Score

178

Pathway Edits

SlGAD1 glutamate decarboxylase isoform 1 overexpression under fruit-ripening promoter for GABA accumulation from free glutamate in ripening tomato pericarp
SlGAD2 isoform 2 co-overexpression via bidirectional promoter for expanded GABA biosynthesis capacity across fruit development stages
SlGABA-T GABA transaminase RNAi knockdown (70%) to block GABA catabolism to succinate-semialdehyde, preserving GABA pool for mGluR1 modulation
SlSSADH succinate-semialdehyde dehydrogenase partial suppression (40%) to slow downstream GABA shunt flux without TCA cycle impairment

Key Interventions

GABA mGluR1 allosteric modulation via GAD1/GAD2 upregulation and GABA-T suppression for sustained GABA pool in tomato fruitVacuolar GABA compartmentalization via VAT overexpression for processing-triggered release and mGluR1 activation in food matrixGABA-glutamate balance engineering preventing glutamate depletion while maximizing GABA accumulation for dual mGluR1 signaling

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

178

IFI-B

—

IFI-K

—

IFI-C

—

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Functional tomato products targeting GABA-enriched umami profiles for health-conscious consumers. Applicable to tomato-based beverages, reduced-sodium sauces, and nutraceutical flavor systems claiming natural GABA content.

License

$699 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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