IFI-S · Sorbitol-to-Sweetness Series
Specimen SS-F-SWT-625 // SWEET · IFI-S
Sorbitol-to-Sweetness Series IV-AG-A
Saccharum officinarum
Sugarcane
Tier IVSorbitol-to-Sweetness Series
Target Trait
2.73×
fold-change
Sorbitol accumulation fold-change
Technical Specifications
SKU
SS-F-SWT-625
Genomic Edits
6
GC Content
46.7%
Construct Length
3,629 bp
Promoter System
35S CaMV promoter
Expression System
Agrobacterium-mediated T-DNA
Host Strain
EHA105
Receptor Target
TAS1R2/TAS1R3
IFI Score
273
Pathway Edits
- S6PDH sorbitol-6-phosphate dehydrogenase overexpression for direct conversion of glucose-6-P to sorbitol
- SDH sorbitol dehydrogenase downregulation to prevent catabolism of accumulated sorbitol
- SPS sucrose phosphate synthase activity optimization for sucrose-sorbitol metabolic balance
- SPP sucrose phosphate phosphatase co-expression for enhanced sucrose-to-sorbitol flux management
- Fructokinase activity suppression to redirect fructose toward the sorbitol biosynthetic route
- Vacuolar H+-ATPase upregulation for enhanced sorbitol compartmentalization in sugarcane
- SWEET transporter expression for optimized sorbitol loading into phloem and sink tissues
Key Interventions
S6PDH overexpression for direct glucose-6-phosphate conversion to sorbitol in sugarcaneSDH downregulation preventing sorbitol catabolism to maintain high steady-state accumulationSPS co-optimization balancing sucrose-sorbitol carbon partitioning for desired sweetness profile
IFI Subscale Profile
IFI Profile
IFI-S273
IFI-U—
IFI-B—
IFI-K—
IFI-C—
IFI-P—
IFI-A—
IFI-F—
Use Case
regulatory metabolite profiling for sorbitol-enhanced sugarcane as a natural polyol ingredient
License
$3999 · Tier IV License
Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.
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