Specimen SS-F-SWT-400 // SWEET · IFI-S
Mogrol Precursor Series V-IV-B
Momordica grosvenorii
Monk Fruit
Target Trait
4×
fold-change
Mogrol precursor fold-change
Technical Specifications
SKU
SS-F-SWT-400
Genomic Edits
8
GC Content
44.2%
Construct Length
4,395 bp
Promoter System
T7/SP6 promoter
Expression System
Cell-free transcription/translation
Host Strain
T7 RNAP + wheat germ extract
Receptor Target
TAS1R2/TAS1R3
IFI Score
400
Pathway Edits
- HMGR 3-hydroxy-3-methylglutaryl-CoA reductase upregulation for enhanced MVA pathway flux
- HMGS HMG-CoA synthase overexpression for increased acetyl-CoA channeling to MVA pathway
- SQS squalene synthase expression enhancement for conversion of FPP to squalene
- SE squalene epoxidase activity optimization for 2,3-oxidosqualene production
- CYP87D18 integration for downstream mogrol cyclization from oxidosqualene substrate
- Sterol pathway suppression to redirect squalene flux toward mogroside precursors
- Farnesyl diphosphate synthase upregulation for FPP precursor pool expansion
Key Interventions
IFI Subscale Profile
IFI Profile
Use Case
Enhanced performance variant: industrial MVA pathway optimization in Momordica for scalable triterpenoid sweetener production with amplified TAS1R2/TAS1R3 receptor activation for premium-tier applications
License
$10049 · Tier V License
Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.
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