IFI-S · Mogrol Precursor Series
Specimen SS-F-SWT-399 // SWEET · IFI-S
Mogrol Precursor Series V-IV-A
Momordica grosvenorii
Monk Fruit
Tier VMogrol Precursor Series
Target Trait
4×
fold-change
Mogrol precursor fold-change
Technical Specifications
SKU
SS-F-SWT-399
Genomic Edits
8
GC Content
47.4%
Construct Length
4,378 bp
Promoter System
T7/SP6 promoter
Expression System
Cell-free transcription/translation
Host Strain
T7 RNAP + wheat germ extract
Receptor Target
TAS1R2/TAS1R3
IFI Score
400
Pathway Edits
- HMGR 3-hydroxy-3-methylglutaryl-CoA reductase upregulation for enhanced MVA pathway flux
- HMGS HMG-CoA synthase overexpression for increased acetyl-CoA channeling to MVA pathway
- SQS squalene synthase expression enhancement for conversion of FPP to squalene
- SE squalene epoxidase activity optimization for 2,3-oxidosqualene production
- CYP87D18 integration for downstream mogrol cyclization from oxidosqualene substrate
- Sterol pathway suppression to redirect squalene flux toward mogroside precursors
- Farnesyl diphosphate synthase upregulation for FPP precursor pool expansion
Key Interventions
HMGR and HMGS co-upregulation driving MVA pathway flux toward triterpenoid precursorsSQS overexpression directing flux toward squalene for mogrol precursor availabilityCYP87D18 downstream integration converting oxidosqualene to mogrol aglycone
IFI Subscale Profile
IFI Profile
IFI-S400
IFI-U—
IFI-B—
IFI-K—
IFI-C—
IFI-P—
IFI-A—
IFI-F—
Use Case
industrial MVA pathway optimization in Momordica for scalable triterpenoid sweetener production
License
$9999 · Tier V License
Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.
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