IFI-S · Mogrol Precursor Series

Specimen SS-F-SWT-384 // SWEET · IFI-S

Mogrol Precursor Series III-IV-B

Momordica grosvenorii

Monk Fruit

Tier IIIMogrol Precursor Series

Target Trait

2.75×

fold-change

Mogrol precursor fold-change

Technical Specifications

SKU

SS-F-SWT-384

Genomic Edits

6

GC Content

44.3%

Construct Length

3,501 bp

Promoter System

T7/SP6 promoter

Expression System

Cell-free transcription/translation

Host Strain

T7 RNAP + wheat germ extract

Receptor Target

TAS1R2/TAS1R3

IFI Score

275

Pathway Edits

  • HMGR 3-hydroxy-3-methylglutaryl-CoA reductase upregulation for enhanced MVA pathway flux
  • HMGS HMG-CoA synthase overexpression for increased acetyl-CoA channeling to MVA pathway
  • SQS squalene synthase expression enhancement for conversion of FPP to squalene
  • SE squalene epoxidase activity optimization for 2,3-oxidosqualene production
  • CYP87D18 integration for downstream mogrol cyclization from oxidosqualene substrate
  • Sterol pathway suppression to redirect squalene flux toward mogroside precursors

Key Interventions

HMGR and HMGS co-upregulation driving MVA pathway flux toward triterpenoid precursorsSQS overexpression directing flux toward squalene for mogrol precursor availabilityCYP87D18 downstream integration converting oxidosqualene to mogrol aglycone

IFI Subscale Profile

IFI Profile

IFI-S
275
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Enhanced performance variant: commercial mogrol precursor accumulation for efficient mogroside V biotransformation feedstock supply with amplified TAS1R2/TAS1R3 receptor activation for premium-tier applications

License

$1549 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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