CU Sequential Integration Series I-PR-B

Mentha × piperita

Peppermint

Tier ICU Sequential Integration Series

Target Trait

1.46×

fold-change

Cooling+Umami sequential pathway fold-change

Technical Specifications

SKU

SS-F-M2-03968

Genomic Edits

GC Content

45.2%

Construct Length

3,567 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-mediated

Receptor Target

TRPM8 + mGluR1

IFI Score

146

Pathway Edits

TRPM8 pathway primary gene cluster overexpression for cooling axis activation
mGluR1 pathway primary gene cluster overexpression for umami axis activation
Bidirectional promoter system for synchronized C+U dual-axis co-expression
Metabolic flux partitioning between IFI-C and IFI-U pathway branches via carbon flow optimization
Transcription factor co-binding site engineering for Cooling-Umami combinatorial gene regulation
Cross-pathway feedback inhibition circuit removal for C+U simultaneous accumulation

Key Interventions

Dual-receptor co-activation via synchronized TRPM8 and mGluR1 pathway engineeringMetabolic flux partitioning strategy enabling simultaneous cooling and umami accumulation without competing pathway suppressionSequential construct stacking for CU multi-axis integrationPEG-mediated co-transfection of axis constructs for rapid phenotypic screening of multi-axis combinations

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

—

IFI-B

—

IFI-K

—

IFI-C

—

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Tier I CU dual-axis sequential integration platform for food ingredient applications requiring verified combined cooling+umami sensory character. Suitable for multi-modal flavor architecture, premium ingredient certification, and receptor-confirmed IFI multi-axis profiling.

License

$349 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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