IFI-K · Kokumi-Rich Allium Total Engineering

Specimen SS-F-KOK-965 // KOKUMI · IFI-K

Kokumi-Rich Allium Total Engineering I-PR-A

Allium sativum

Garlic

Tier IKokumi-Rich Allium Total Engineering

Target Trait

2×

fold-change

Comprehensive kokumi compound co-production fold-change in Allium sativum

Technical Specifications

SKU

SS-F-KOK-965

Genomic Edits

6

GC Content

43.9%

Construct Length

3,516 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-4000

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

200

Pathway Edits

  • GCL/GS comprehensive GSH pathway co-engineering for primary kokumi compound foundation
  • GAD1 high-flux GABA production cassette for CaSR allosteric modulator co-production
  • SPDS spermidine synthesis activation for polyamine CaSR ligand co-engineering
  • ACSO-lyase SAC production for S-allyl-cysteine CaSR agonist co-expression
  • SAT cysteine sulfoxide channeling for alliin and SAC precursor flux optimization
  • GGT1 γ-glutamyl transpeptidation for dipeptide and tripeptide CaSR ligand decoration
  • Multi-compound pathway flux balancing via transcriptional co-regulator expression
  • Metabolic hub optimization for simultaneous GSH, GABA, spermidine and SAC production

Key Interventions

GCL/GS/GAD1/SPDS comprehensive four-compound kokumi co-production for full-spectrum CaSR occupancyACSO-lyase/SAT SAC and alliin CaSR ligand co-engineering for sulfur agonist spectrum amplificationGGT1 γ-glutamyl transpeptidation for maximal broad-spectrum CaSR occupancy across all ligand classesProtoplast PEG-fusion delivery optimized for Allium sativum genome accessibilityTier-I construct validated with 6 precision edits for 2× fold-change

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
200
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Research-grade total Allium kokumi reference for comprehensive CaSR multi-ligand mechanism studies

License

$299 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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