IFI-K · Lanthionine Peptide
Specimen SS-F-KOK-598 // KOKUMI · IFI-K
Lanthionine Peptide V-PR-B
Saccharomyces cerevisiae
Yeast
Tier VLanthionine Peptide
Target Trait
3.89×
fold-change
Cyclic lanthipeptide-analog CaSR ligand fold-change in Saccharomyces cerevisiae
Technical Specifications
SKU
SS-F-KOK-598
Genomic Edits
10
GC Content
46.9%
Construct Length
5,121 bp
Promoter System
Ubiquitin / T7
Expression System
Protoplast PEG-fusion
Host Strain
PEG-4000
Receptor Target
CaSR (calcium-sensing receptor)
IFI Score
389
Pathway Edits
- LANM (lanthipeptide modifying enzyme homolog) activity-tuned expression for Lan dehydration
- LANB (lanthipeptide biosynthesis protein B) protease expression for leader peptide cleavage
- LanC-like cyclase expression for lanthionine ring structure formation in yeast
- ProcA precursor peptide cassette expression with optimized leader sequence
- Lanthipeptide ABC transporter expression for extracellular cyclic peptide secretion
- Lan-RG (lanthipeptide regulator/immunity protein) expression for pathway stability
- Prepeptide processing protease expression for mature cyclic CaSR ligand liberation
Key Interventions
LANM/LANB lanthipeptide modification and cleavage pathway for cyclic CaSR peptide scaffold productionLanC-like cyclase expression for lanthionine ring formation creating conformationally constrained CaSR ligandProcA precursor and ABC transporter for extracellular accumulation of mature cyclic kokumi compoundProtoplast PEG-fusion delivery optimized for Saccharomyces cerevisiae genome accessibilityTier-V construct validated with 10 precision edits for 3.89× fold-change
IFI Subscale Profile
IFI Profile
IFI-S—
IFI-U—
IFI-B—
IFI-K389
IFI-C—
IFI-P—
IFI-A—
IFI-F—
Use Case
Ultra-premium lanthipeptide CaSR ligand for luxury yeast-fermented kokumi product lines
License
$10049 · Tier V License
Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.
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