IFI-K · Lanthionine Peptide

Specimen SS-F-KOK-581 // KOKUMI · IFI-K

Lanthionine Peptide III-PR-A

Saccharomyces cerevisiae

Yeast

Tier IIILanthionine Peptide

Target Trait

2.5×

fold-change

Cyclic lanthipeptide-analog CaSR ligand fold-change in Saccharomyces cerevisiae

Technical Specifications

SKU

SS-F-KOK-581

Genomic Edits

7

GC Content

45.1%

Construct Length

4,030 bp

Promoter System

Ubiquitin / T7

Expression System

Protoplast PEG-fusion

Host Strain

PEG-4000

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

250

Pathway Edits

  • LANM (lanthipeptide modifying enzyme homolog) activity-tuned expression for Lan dehydration
  • LANB (lanthipeptide biosynthesis protein B) protease expression for leader peptide cleavage
  • LanC-like cyclase expression for lanthionine ring structure formation in yeast
  • ProcA precursor peptide cassette expression with optimized leader sequence
  • Lanthipeptide ABC transporter expression for extracellular cyclic peptide secretion
  • Lan-RG (lanthipeptide regulator/immunity protein) expression for pathway stability
  • Prepeptide processing protease expression for mature cyclic CaSR ligand liberation

Key Interventions

LANM/LANB lanthipeptide modification and cleavage pathway for cyclic CaSR peptide scaffold productionLanC-like cyclase expression for lanthionine ring formation creating conformationally constrained CaSR ligandProcA precursor and ABC transporter for extracellular accumulation of mature cyclic kokumi compoundProtoplast PEG-fusion delivery optimized for Saccharomyces cerevisiae genome accessibilityTier-III construct validated with 7 precision edits for 2.5× fold-change

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
250
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Commercial yeast-fermented lanthipeptide analog concentrate for beverage and sauce kokumi

License

$1499 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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