IFI-K · S-Allyl-Cysteine

Specimen SS-F-KOK-321 // KOKUMI · IFI-K

S-Allyl-Cysteine I-AG-A

Allium sativum

Garlic

Tier IS-Allyl-Cysteine

Target Trait

1.6×

fold-change

SAC (S-allyl-L-cysteine) CaSR agonist fold-change vs baseline

Technical Specifications

SKU

SS-F-KOK-321

Genomic Edits

4

GC Content

44.2%

Construct Length

2,808 bp

Promoter System

Tissue-specific 2A11 / CaMV 35S

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Receptor Target

CaSR (calcium-sensing receptor)

IFI Score

160

Pathway Edits

  • ACSO-lyase (alliin lyase) expression for S-allyl cysteine sulfoxide to SAC conversion
  • GCL upregulation for cysteine-precursor supply to S-allylation pathway
  • CS-lyase (cystathionine γ-lyase) activity enhancement for C-S bond formation
  • SAM-SAT (S-adenosylmethionine dependent allyl transferase) allyl group donor pathway
  • Allyl-CoA channel engineering for cytosolic S-allyl donor availability
  • CSE (cystathionine β-synthase-related enzyme) expression for cysteine intermediate
  • Cysteine sulfoxide permease upregulation for SAC extracellular release and bioavailability

Key Interventions

ACSO-lyase expression to establish SAC biosynthesis as potent CaSR agonist in Allium sativumGCL cysteine precursor supply and CS-lyase C-S bond formation for allyl-cysteine scaffoldSAM-SAT allyl activation pathway for high-flux S-allyl group incorporation into cysteine acceptorAgrobacterium-mediated T-DNA delivery optimized for Allium sativum genome accessibilityTier-I construct validated with 4 precision edits for 1.6× fold-change

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
160
IFI-C
—
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Research-grade SAC kokumi reference for CaSR agonist potency screening and R&D

License

$299 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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