IFI-C · trans-p-Menthane

Specimen SS-F-CLB-936 // COOL BURN · IFI-C

trans-p-Menthane II-IV-B

Mentha × piperita

Peppermint

Tier IItrans-p-Menthane

Target Trait

1.59×

fold-change

trans-p-menthane accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-936

Genomic Edits

5

GC Content

47.3%

Construct Length

3,274 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

159

Pathway Edits

  • MH1 (menthane hydroxylase 1) codon-optimized overexpression for p-menthane scaffold oxidation
  • CYP71A (cytochrome P450 71A family) stereoselective variant for trans-menthane hydroxylation
  • CMK2 (methylerythritol phosphate kinase 2) MEP pathway amplification for precursor supply
  • trans-p-Menthane oxidase suppression to prevent scaffold degradation

Key Interventions

trans-p-Menthane TRPM8 scaffold overproduction via MH1/CYP71A stereoselective engineeringCMK2 MEP pathway amplification for sustained menthane precursor availabilityTRPM8 receptor activation with saturated menthane scaffold distinct from oxygenated menthol

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
159
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Menthane scaffold ingredient development, mild-cooling formulation, non-oxygenated menthane ingredient sourcing, and applications requiring subtle woody-cooling TRPM8 character for sophisticated flavor profiles.

License

$749 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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