IFI-C · Terpineol Cooling

Specimen SS-F-CLB-912 // COOL BURN · IFI-C

Terpineol Cooling IV-IV-B

Mentha × piperita

Peppermint

Tier IVTerpineol Cooling

Target Trait

2.74×

fold-change

alpha-terpineol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-912

Genomic Edits

6

GC Content

46.2%

Construct Length

3,508 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

274

Pathway Edits

  • TPS-TER (terpineol-selective terpene synthase) codon-optimized overexpression in Mentha × piperita
  • GPPS (geranyl pyrophosphate synthase) upregulation for GPP/LPP precursor flux
  • DXS (1-deoxy-D-xylulose 5-phosphate synthase) MEP pathway rate-limiting amplification
  • Terpineol hydratase suppression to prevent alpha-terpineol hydration to terpineol-4-ol

Key Interventions

Alpha-terpineol TRPM8 agonist overproduction via TPS-TER/GPPS co-upregulation in MenthaMEP pathway DXS amplification for enhanced IPP/DMAPP precursor availabilityTRPM8 activation with lilac-floral-pine cooling character distinct from menthol

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
274
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Industrial alpha-terpineol crop platform, next-generation floral-cooling ingredient supply chains, clinical TRPM8 floral agonist research sourcing, and high-yield terpineol-enriched Mentha cultivar programs.

License

$4049 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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