Terpineol Cooling III-IV-A

Mentha × piperita

Peppermint

Tier IIITerpineol Cooling

Target Trait

1.95×

fold-change

alpha-terpineol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-903

Genomic Edits

GC Content

43.8%

Construct Length

3,144 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

195

Pathway Edits

TPS-TER (terpineol-selective terpene synthase) codon-optimized overexpression in Mentha × piperita
GPPS (geranyl pyrophosphate synthase) upregulation for GPP/LPP precursor flux
DXS (1-deoxy-D-xylulose 5-phosphate synthase) MEP pathway rate-limiting amplification
Terpineol hydratase suppression to prevent alpha-terpineol hydration to terpineol-4-ol

Key Interventions

Alpha-terpineol TRPM8 agonist overproduction via TPS-TER/GPPS co-upregulation in MenthaMEP pathway DXS amplification for enhanced IPP/DMAPP precursor availabilityTRPM8 activation with lilac-floral-pine cooling character distinct from menthol

IFI Subscale Profile

IFI Profile

IFI-S

—

IFI-U

—

IFI-B

—

IFI-K

—

IFI-C

195

IFI-P

—

IFI-A

—

IFI-F

—

Use Case

Premium alpha-terpineol ingredient supply, floral-pine functional food cooling development, pharmaceutical grade terpineol ingredient production, and novel floral TRPM8 agonist platform creation.

License

$1499 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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