IFI-C · Terpineol Cooling

Specimen SS-F-CLB-888 // COOL BURN · IFI-C

Terpineol Cooling I-IV-B

Mentha × piperita

Peppermint

Tier ITerpineol Cooling

Target Trait

1.26×

fold-change

alpha-terpineol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-888

Genomic Edits

4

GC Content

46.0%

Construct Length

2,847 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

126

Pathway Edits

  • TPS-TER (terpineol-selective terpene synthase) codon-optimized overexpression in Mentha × piperita
  • GPPS (geranyl pyrophosphate synthase) upregulation for GPP/LPP precursor flux
  • DXS (1-deoxy-D-xylulose 5-phosphate synthase) MEP pathway rate-limiting amplification
  • Terpineol hydratase suppression to prevent alpha-terpineol hydration to terpineol-4-ol

Key Interventions

Alpha-terpineol TRPM8 agonist overproduction via TPS-TER/GPPS co-upregulation in MenthaMEP pathway DXS amplification for enhanced IPP/DMAPP precursor availabilityTRPM8 activation with lilac-floral-pine cooling character distinct from menthol

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
126
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Lilac-pine flavor ingredient development, floral-cooling confectionery formulation, non-menthol TRPM8 agonist ingredient sourcing, and cosmetic fragrance-cooling applications requiring alpha-terpineol character.

License

$349 · Tier I License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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