IFI-C · PMD Cooling

Specimen SS-F-CLB-818 // COOL BURN · IFI-C

PMD Cooling III-AG-B

Eucalyptus globulus

Eucalyptus

Tier IIIPMD Cooling

Target Trait

2.59×

fold-change

p-menthane-3,8-diol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-818

Genomic Edits

6

GC Content

48.2%

Construct Length

3,679 bp

Promoter System

Tissue-specific 2A11

Expression System

Agrobacterium-mediated T-DNA

Host Strain

EHA105

Receptor Target

TRPM8

IFI Score

259

Pathway Edits

  • CYP76C (cytochrome P450 76C family) stereoselective variant for p-menthane hydroxylation
  • GNPS (geraniol-nerol phosphate synthase) upregulation for citronellol pathway flux
  • GDR (geranyl diphosphate reductase) upregulation for citronellal precursor availability
  • CMK (methylerythritol phosphate kinase) MEP pathway amplification for precursor supply
  • PMD oxidase suppression cassette to prevent PMD degradation

Key Interventions

p-menthane-3,8-diol TRPM8 agonist overproduction via CYP76C/GNPS co-engineeringGDR/CMK MEP pathway co-upregulation for sustained citronellol precursor provisionTRPM8 receptor activation with distinct lemon-eucalyptus cooling character

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
259
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Premium PMD ingredient supply, lemon-eucalyptus pharmaceutical ingredient production, functional food eucalyptus-cooling development, and novel non-menthol TRPM8 agonist platform creation.

License

$1549 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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