IFI-C · PMD Cooling

Specimen SS-F-CLB-815 // COOL BURN · IFI-C

PMD Cooling II-IV-A

Eucalyptus globulus

Eucalyptus

Tier IIPMD Cooling

Target Trait

1.78×

fold-change

p-menthane-3,8-diol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-815

Genomic Edits

4

GC Content

45.4%

Construct Length

2,837 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

178

Pathway Edits

  • CYP76C (cytochrome P450 76C family) stereoselective variant for p-menthane hydroxylation
  • GNPS (geraniol-nerol phosphate synthase) upregulation for citronellol pathway flux
  • GDR (geranyl diphosphate reductase) upregulation for citronellal precursor availability
  • CMK (methylerythritol phosphate kinase) MEP pathway amplification for precursor supply
  • PMD oxidase suppression cassette to prevent PMD degradation

Key Interventions

p-menthane-3,8-diol TRPM8 agonist overproduction via CYP76C/GNPS co-engineeringGDR/CMK MEP pathway co-upregulation for sustained citronellol precursor provisionTRPM8 receptor activation with distinct lemon-eucalyptus cooling character

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
178
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Natural insect-repellent ingredient development, lemon-eucalyptus flavor formulation, PMD cosmetic ingredient sourcing, and functional cooling applications requiring eucalyptus-citrus TRPM8 character.

License

$699 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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